Modulating macrophage function with IgG immune complexes
نویسندگان
چکیده
منابع مشابه
Modulating IgG effector function by Fc glycan engineering.
IgG antibodies contain a conserved N-glycosylation site on the Fc domain to which a complex, biantennary glycan is attached. The fine structures of this glycan modulate antibody effector functions by affecting the binding affinity of the Fc to diverse Fc receptor family members. For example, core fucosylation significantly decreases antibody-dependent cellular cytotoxicity (ADCC), whereas termi...
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OBJECTIVE Immune complexes containing oxidatively modified low-density lipoprotein (oxLDL) particles are deposited in human atherosclerotic lesions during atherogenesis. Here we studied whether OxLDL-IgG immune complexes (OxLDL-IgG ICs) affect survival of human monocytes. METHODS AND RESULTS As demonstrated by light microscopy, and analysis of cell proliferation, caspase-3 activity, and DNA f...
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A paradox in monoclonal antibody (mAb) therapy is that despite the well-documented tolerogenic properties of deaggregated IgG, most therapeutic IgG mAb induce anti-mAb responses. To analyze CD4 T cell reactions against IgG in various physical states, we developed an adoptive transfer model using CD4+ T cells specific for a Vκ region-derived peptide in the hapten-specific IgG mAb 36-71. We found...
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ژورنال
عنوان ژورنال: Journal of Endotoxin Research
سال: 2002
ISSN: 0968-0519
DOI: 10.1177/09680519020080060501